RESVERATROL - New Research, 4 Papers Reviewed and Potential Use in Protecting the Alkaline Design of the Body Fluids and Cells

Resveratrol is a powerful alkalizing compound reducing the risk for any of the seven stages of acidosis - stage 1 enervation (loss of energy), stage 2 sensitivities (allergies), stage 3 irritation, stage 4 inflammation (pain), stage 5 induration (crystals, stones, plague), stage 6 ulceration (lesions) and stage 7 degeneration (cancer, multiple sclerosis, alzheimers)

RESVERATROL - New research, 4 papers reviewed and potential use in protecting the alkaline design of the body fluids and cells -

Papers Reviewed:

• (2020 April, Berretta et al) - Resveratrol in Cancer Patients: From Bench to Bedside

• (2022, April, Almatroodi) - Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer

• (2022 Nov, Jang et al) - Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review

• (2023 Nov, Kursvietiene et al) - Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
  

2020 April, Berretta et al - Resveratrol in Cancer Patients: From Bench to Bedside

• Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several green vegetables and green fruit like avocado, cucumbers, broccoli, spinach, wheat and barley grass, purple grapes, red fruit, green olives, capers, just to name a few (few to the list of foods to eat freely in The pH Miracle revised and updated book - www.phmiracleproducts.com)

• This interesting bioactive compound is well known as an anti exotoxic, anti mycotoxic or anti acidic and therefore anti-inflammatory agent; however, in the last 10 years, researchers worldwide have exponentially increased the study on its biological properties

• Resveratrol is one of the most studied alkalizing and acid chelating polyphenols

• Resveratrol is naturally produced from phenylalanine in response to exogenous stimuli from exotoxins and mycotoxins from fungi and metabolic wastes of lactic and citric acids leading to outfections

• Resveratrol has a good safety profile and has a very wide spectrum of targets
  

Anti-Acidic Properties

• foods that have resveratrol are common in the pH Miracle Live-it lifestyle

• the anticancerous effects of Resveratrol are the result of reducing acids in and around the body cells

• anti-oxidant or antacids effects in reducing metabolic, dietary, respiratory and environmental acids that lead to inflammation, induration, ulcerations and degenerative and the release of ROS (reactive oxygen species) to restore the alkaline design of the body fluids

• anti-inflammation or antacid effects (down regulates production of inflammatory cytokines, inhibits NF-κB)

• Downregulates HIF-1α, a transcription factor regulating the expression of more than a hundred microzymian gene constructs, is overly expressed from pathological blood coagulation leading to hypoxia, promoting more alarming acidic conditions of ulceration and degeneration of body cells that make up tissues, organs and glands,

• inhibits angiogenesis

2022, April, Almatroodi - Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer

• Resveratrol is a well known polyphenol, a component of purple grapes that have it in modest concentration. It is a member of the stilbene family.

• Resveratrol has confirmed roles in any cancerous acidic condition because it activates tumor suppressor genes, suppresses cell proliferation, induces apoptosis, inhibits angiogenesis, and modulates several other cell signaling molecules
  

Anti-Acid or AntiCancerous Effects

• Antioxidant - it has ability to remove acid and support the alkalizing effects ROS (reactive oxygen species)

• Anti-inflammatory effects (multiple)

• increases expression of p53 and PTEN

• apoptosis - triggers apoptosis by suppressing AKT pathway

• angiogenesis - decreases expression of VEFG (vascular endothelial growth factor)

• shown in vivo in mice studies

• Inactivates STAT signaling in fermenting inflammatory and cancerous cells - inhibits cell proliferation, triggers apoptosis or reverse transformation back to the microzymian indestructible matter

• cell cycle arrest - induces cell cycle arrest because you are increasing the alkaline design of the body fluids

Key actions on certain cancerous conditions

• esophageal cancer - in a study with rats that had esophagitis, Resveratrol prevented a cancerous condition from forming (via COX-2 suppression) by restoring the alkaline design of the surrounding and intracellular fluids

• lung cancer - Resveratrol activates p53 tumor suppressor gene and its proapoptotic modulator. Inhibits reverse transformation of the cell proliferation and stimulates apoptosis

• also induced autophagy in lung cancerous cells

• cholangiocarcinoma, gastric cancer - Resveratrol inhibited IL-6 secretion by restoring the alkaline design of the interstitial and intracellular fluids

• IL-6 increases reverse transformation of any cancerous cell migration and elimination out through the various offices of the body

• pancreatic cancer acidity - Resveratrol inhibited proliferation by inducing ROS and multiple other pathways including cell cycle arrest

• colon cancer acidity - induced ROS, cell cycle arrest, etc.

• renal cell acidity - In a concentration- and time-dependent way, resveratrol inhibited renal cell carcinoma cell growth, migration, and invasion (inhibition of Akt path)

• prostate cancer acidity - resveratrol significantly increased the expressions of p53 and HIF-1α in prostate cancer cells

• resveratrol encourages apoptosis through p53/HIF-1α/ROS signaling in prostate cancer cells

• resveratrol in conjunction with an androgen receptor and CXCR4 antagonists can be utilized to reduce prostate cancer metastatic behavior by increasing alkalinity in the surrounding fluids and intracellular cells 

• Urinary bladder cancer acidity - combination of rapamycin and resveratrol was thought to be very effective in inhibiting mTOR and PI3K signaling while also inducing cell death in bladder cancer cells

• breast cancer acidity - resveratrol may operate as a potential inducer to increase the chemosensitivity of breast cancer cell

• involvement of resveratrol in the decrease of breast cancer cells with stemness markers was recently discovered

• endometrial cancer acidity - apoptosis, cell cycle arrest

• cervical cancer acidity - apoptosis, cell cycle arrest, increased p53 expression, inhibit matrix metalloproteinases

• ovarian cancer acidity - inhibits IL-6, apoptosis

• uterine cancer acidity - apoptosis

• lymphoma acidity - apoptosis, cell cycle arrest, numerous mechanisms.

• melanoma acidity - apoptosis, cell cycle arrest, resveratrol reduced microRNA expression

• leukemia acidity - apoptosis

• brain cancer acidity - combined therapy resveratrol and paclitaxel
  

Safety and Efficacy

• A number of human clinical trials show resveratrol has a therapeutic role in reversing any cancerous condition

• Phase I/II Study with biochemically recurrent prostate cancer acidity (14 men) showed safety of a dose of Resveratrol up to 4000mg/day (2001, Adhami et al)

• Colorectal cancer & liver mets acidity - 5000mg/day x 14 days (2015, Paller et al)
  

Resveratrol combined with Highly Acidic Cancer Drugs

• combination therapy Resveratrol with anti inflammatory, anti acidity effects of blood, interstitial and intracellular fluids may lower the acidic toxic side effects with anticancer drugs

2022 Nov, Jang et al) - Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review

• Resveratrol is a phytoalexin produced by plants in response to injury by pathogens such as bacteria and fungi

• Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a polyphenol found in purple grapes has been reported to exhibit a wide range of biological and pharmacological properties

• resveratrol has been reported to intervene in multiple stages of carcinogenesis.

• resveratrol is rapidly metabolized and eliminated
  

Human trials

• ClinicalTrials.gov shows 198 active Human Trials with Resveratrol including 12 involving a cancerous acidic condition.

• 4 in colorectal acidic cancerous conditions

• 2 skin acidic cancerous conditions

• 2 breast acidic cancerous conditions

• 1 liver acidic cancerous condition

• 1 follicular lymphoma acidic condition

• 1 multiple myeloma acidic condition

• 1 neuroendocrine acidic cancerous condition
  

Resveratrol and p53

• p53 is a tumor suppressor that modulates cellular responses to micorzymian genotoxic stress

• Activation of p53 induces the transcription of target genes involved in cell cycle arrest, DNA repair, and apoptosis

• Resveratrol can target the p53-mediated pathway to induce apoptosis

• resveratrol enhanced the expression of p53 and p53 target genes, including Bax and PUMA, which play a pivotal role in p53-dependent apoptosis

• Mutations in p53 have been observed in more than 50% of human acidic tumor tissues.

• “Loss of p53 function in certain tumor types is associated with chemoresistance, and acidic cancerous conditions with p53 mutations are generally poorly responsive to therapeutic agents,”
  

Resveratrol and Autophagy

• Derived from the Greek “self-eating”, the term autophagy describes the catabolic process by which cytoplasmic cargo is delivered to lysosomes for degradation and recycling

• In early microzyma tumorigenesis, autophagy inhibits tumor initiation and suppresses cancer progression through survival pathways and quality control mechanisms

• Autophagy is implicated in Resveratrol’s effect on many acidic cancerous conditions: breast, colon, cervical, esophageal, gastric, leukemia, lung, liver, multiple myeloma, oral ovarian acidic cancerous conditions.

Drawbacks:

• “Resveratrol is very photosensitive, poorly soluble in water, has a short biological half-life, and is rapidly metabolized and eliminated, thus limiting its clinical application”

2023 Nov, Kursvietiene et al) - Anti-Cancerous Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

• Resveratrol serves as a powerful alkalizing antioxidant in plants, protecting against photodamage.

• Furthermore, resveratrol is recognized as a phytoalexin. Plants synthesize such chemicals to protect them from stress induced by metabolic, dietary, respiratory and environmental acids giving rise to cellular pleomorphism and the creation of fungi, bacteria and ultra blue and ultraviolet UV radiation from car lights, street lights and computers, just to name a few.
  

• Resveratrol also targets fermenting and damaged stem cells which are pivotal in tumor initiation and recurrence.

• Resveratrol has been demonstrated to suppress tumor activity in lung cancer, specifically by inhibiting lung cancer stem-like cell stemness and reducing IL-6 levels

• Resveratrol has numerous anti-cancer effects: autophagy, apoptosis, ROS levels, DNA repair, targeting cancer stem cells, inhibiting miRNAs

• Resveratrol suppresses tumor progression by inducing cell cycle arrest, activation of apoptosis, inhibiting angiogenesis and inhibiting metastasis caused by ferments from the fermenting and degenerating cells

• “Innovative delivery systems, such as polymeric nanoparticles, liposomes, micelles, and metallic nanoparticles, could enhance resveratrol stability, solubility, and ability to permeate biological membranes, ensuring more efficient access to cancer cells”

• “When combined with other anticancer drugs (chemo), resveratrol has shown potential in increasing their cytotoxic effects and decreasing the associated side effects.”
  

Tumor mitochondria:

• Mitochondria are the main producer of ROS (reactive oxygen species) in an attempt to maintain the alkaline design of the interstitial and intracellular fluids

• DNA damage inflicted by acidic metabolic, dietary, environmental and respiratory poisons can be especially dangerous for the cell, leading to mutations, some of which might provide a selective growth advantage, driving tumorigenesis and the progression of malignancies

• Mitochondria play a crucial role in the regulation of apoptosis, often known as programmed cell death. In response to cellular stress, cells can release pro-apoptotic substances

• p53, commonly referred to as the “guardian of the genome”, is a tumor suppressor protein, which plays a crucial role in safeguarding against cancer

• p53 regulates cell health by pausing the cell cycle to facilitate DNA repair upon detecting damage and by initiating apoptosis to eliminate cells when damage is irreparable.

• p53 inhibits angiogenesis, which prevents tumors from developing the blood vessels they need to grow. In many cancers, a dysfunctional p53 pathway, resulting from mutations in either p53 or its regulatory components, impedes its role in apoptosis, thereby allowing damaged cells to proliferate uncontrollably.

• “Cancer cells are characterized by their inherent ability to undergo sustained proliferation, escape growth suppressors, and exhibit resistance to programmed cell death. To support these characteristics, they undergo profound metabolic changes, which differentiate them from their normal counterparts. The mitochondria, with their pivotal role in energy production, metabolism, and cell signaling, are at the forefront of these metabolic adaptations.”

• One of the distinctive metabolic signatures of tumor cells is their increased dependence on aerobic glycolysis, commonly referred to as the Warburg effect

• cancer cells predominantly use glycolysis even in ample oxygen, allowing them to rapidly produce ATP crucial for accelerated growth and proliferation.

• cancerous cells have impaired lipid metabolism - lipid biosynthesis is driven by glutamine

• It provides the necessary lipids, which are integral components of cell membranes, thereby supporting the structural and functional needs of rapidly dividing cells.

• Additionally, alterations in lipid metabolism contribute to the activation of several biochemical pathways implicated in both the initiation of a cancerous condition (tumorigenesis) and the process whereby one fermenting cells spoils another cell progressing to other parts of the body (metastasis)

• These pathways, enhanced by the aberrant lipid metabolism, enable cancerous fermenting cells to modulate their environment, resist apoptotic signals, and invade distant tissues, rendering them more aggressive and resilient to conventional therapeutic strategies. Moreover, the products of altered lipid metabolism can also serve as signaling molecules and modulators of microzymian expression, further reinforcing the 'domino effect' of an acidic environment causing more and more cancerous cells

• acidic environment - elevated rate of glycolysis leads to lactic acid and reduction in pH of the extracellular environment, making the interstitial fluids of the Interstitium more acidic.

• Low pH condition triggers the release of pro-inflammatory cytokines and chemokines, leading to the recruitment of inflammatory cells.

• This inflammation within the tumor microenvironment is a well-recognized hallmark of cancer, often associated with enhanced tumor growth, progression, and metastasis

• Mitochondrial enzyme activity is often impaired in tumor cells

• Hyperpolarization of Mitochondria - crucial for many functions including production of ATP

• growth, survival, and aggression of tumor cells depend on mitochondria-driven metabolic changes.
  

Resveratrol Positive Effects on Reducing Fluid Acidity Around the Cells Preventing a Cancerous Condition

• Resveratrol exhibits various anti-acidic properties, including:

• the initiation of apoptosis through mitochondrial pathways

• inhibits aerobic glycolysis (inhibits proliferation) reducing sugars.

• enhances the oxidative stress (acid stress) within the mitochondria, leading to cell damage and death.

• can influence the intracellular calcium levels, thus increasing the pH impacting the homeostasis and metabolic activity of the cell

• targets cancerous stem cells

• alleviates acidic inflammation associated with tumors - by reducing inflammation, resveratrol might also restore the function of immune cells within the tumor, making them more effective in targeting and eliminating cancer cells.

• and promotes the elimination of impaired mitochondria

My Review…

Resveratrol is a very interesting bioactive compound.

It has a number of unique features:

1. Resveratrol is one of the most studied polyphenols

2. Resveratrol has a good safety profile and has a very wide spectrum of targets

3. Most of its ability centers are around apoptosis, autophagy, anti-oxidant, anti-inflammatory, anti-angiogenesis, cell cycle arrest, inhibition of cancer cell signaling, and p53 activation

4. Resveratrol also targets acidic components in the blood and interstitial fluids which are pivotal in tumor initiation and recurrence.

5. Resveratrol also targets numerous processes in cancerous cell mitochondria all of which promote cancer cell breakdown.

6. Resveratrol has been studied in vitro against at least 25 cancers which are summarized by Almatroodi et al (2022).

7. ClinicalTrials.gov shows 198 active Human Trials with Resveratrol including 12 involving cancer. Most studied are: colon cancer (4), breast (2) and skin (2).

Potential use:

Repurposed Drugs - Hydroxychloroquine, Ivermectin, Fenbendazole, Mebendazole - by prescription from your medical doctor

Bioactive compounds, nano colloidal products, synergistic supplements - pH Miracle L-Arginine Max with Resveratrol, Nano Colloidal Marine Plasma Zeolite Z, Innerlight SuperGreens, pH Miracle pHour Salts, pH Miracle puripHy drops, pH Miracle Colloidal glutathione, pH Miracle colloidal N-acetyl-cysteine, iJuice Red Pine Needle Oil and iJuice Black Seed Oil - www.phmiracleproducts.com

Bioactive compounds (Detoxification) - pH Miracle Terra phirma Clay, pH Miracle Liquid Lightning Clay and Salt Baths, pH Miracle pHlush, pH Miracle Master Peace Zeolite Z, pH Miracle C0- Factor Q-10

Bioactive compounds (foods) - garlic, iJuice ginger, iJuice Turmeric, iJuice Chlorophyll, pH Miracle Hemp Seeds and Powder, iJuice Pomegranate, Oregano oil, iJuice Wheatgrass, iJuice Barley grass - www.phmiracleproducts.com

Immune Support - pH Miracle Vitamin D3, pH Miracle K1, pH Miracle Activated Oxygen, pH Miracle Thyroid Support, pH Miracle pHlavor Salts - www.phmiracleproducts.com

Anti Acid Support - pH Miracle pHour salts, WaterMark I alkalizing water purification and ionization system - www.phmiracleproducts.com

Bioactive compounds are crucial in any Alternative Treatment approach to aggressive cancers.

• Resveratrol falls into the category of “supplements”.

• Factors particularly relevant to all acidic conditions, including enervation, irritation, inflammation, induration, ulceration and degeneration

• 1. Resveratrol activates p53 tumor suppressor microzymian gene and its proapoptotic modulator, especially in lung acidic cancer, prostate acidic cancer and cervical acidic cancer (p53 may be damaged in Turbo Cancer as spike protein from cellular degeneration interacts with p53)

• 2. Resveratrol overcomes resistance to chemotherapy which is a very common feature of highly acidic internal environments beginning in the interstitial fluids of the Interstitium leading to Turbo Cancerous condition.
  

I hope this information will help you as you help yourself back to your healthy and energetic alkaline design.